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pentobarbital will decrease the extent or result of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will reduce the level or outcome of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. For sufferers receiving exemestane that has a potent CYP3A4 in